Cyclic condensation products and process of making same



Patented Mar. 10, 1942 UNITED STATES PATENT o CYCLIC CONDENSATIONPRODUCTS AND PROCESS OF MAKING SAME Moses Wolf Goldberg,

signor, by mesne ass Zurich, Switzerland, as-

maceutical Products,

It has been made known by Diels and Amer that suitable reaction partnersso-called philodiene componentswhich possess a system of double and triple linkages, may be caused to add themselves to compounds which possess a system of conjugated double bonds. However,

compounds of the type CC0.R -o 0.11 in which R=hydrogen, alkyl, aryl were not used hitherto to this end. It has now been found that cyclic condensation products are formed when compounds containing a system of conjugated multiple carbon or aralkyl,

linkages, as, for example, any compound containing two ethylene linkages or an ethylene and matic-aliphatic acyl radical, may be employed.-

In the case of the reaction between 1,2-diacetylethylene and 2;3-d.imethyl-buta-1,3-diene, the following is a schematic'illustration of the proc-' ess:

(Ilia CH; H o Co 6 c o-coom a Y J: CH 00 CH 3 3. o on; on, H/

In case, as in the above of the two acyl radicals contains a methylene or methyl group in the oz-position; the condensation products obtained may furthermore be caused to undergo cyclization, under the infiu ence of a dehydrating agent, giving rise tothe formation of a new cyclopentanone ring. For instance, the 1,2-diacetyl-4,5-dimethylcyclohexene-(4) is easily converted by heating, for exreaction partners 1,2-

l-acetyl 2 formylethyle'ne,

1,2-position, are substia instance, at least one i'gnments, to Ciba Phar- Incorporated, Summit, N. J., a corporation of New Jersey No Drawing. Application November 10, 1939, Serial N 303,914. In Switzerland November 11 claims; (or. 260-586) lar those which are generally added in aldo1isa-' tions (of. J. Houben, Die Methoden der organischen Chemie, 3rd.edn., vol. 2, pp. 880, 888 and 945). The cyolization may be brought about also, if desired only. after reduction, of some or of all of theidouble linkages contained in the condensation Product concerned.

Erample 1 2.5 parts of 1,2-diacetyl-ethylen and 2.2,.

parts of 2,3-dimethyl-buta-1,3-diene are boiled in parts of absolute benzene for 6 hours under reflux. The solvent is evaporated and the resi tilled in a vacuum.

. air, and which boils at semicarbazone melts'at 222-223 C.. with decomdue is distilled in a vacuum. The fraction boilingat 185 C. (10 mm.) is taken up in cold pentane, ifrom which it crystallizes. By further the 1,2-diacetyl.-' v melting point 3637 C., is obtained'in the form of 'colourless, prepared in the usual manner. and: recrystallized from methanol,

re-crystallization' from pentane, 4,5-dimethyl-cyclohexene (4) leaves. Its disemicarbazone,

melts at 214.5 C. with decomposition;

'1.2 parts ofthe above cyclohexenederivative,

melting point 3647' 0., are boiled with 60 parts of 0.1 N sodium ethylate solutionin ethanol for 12 hours under reflux. After cooling, some ice and the quantity of'glacial acetic acid, re,- quired for neutralization are a'dded, the solvent is evaporated in a vacuumand the reaction prod;

The ether solution, afterf not taken up in ether'. washing and drying over sodium sulphate; is evaporated, and the tetrahydro-lndoneourless oil, which (3) thus obtained turns yellow on exposure. to

position.

hydrophenanthrene or its derivative is analogous -ly obtained. By starting from the ample, with a solution of sodium methylate'inmethyl alcohol, into the,l,5,6-trimethyl-4,9,7,8- tetrahydro-indone-(3) of the following structural formula: g

To bring about cyclization, use may naturally be made of other dehydrating agents, in particu- In place of the 1,2-diacetyl-ethylene any other 1,2-diacyl-ethylene or -acetylene may beused,

for example, A -1,2'-diacetyl-propene,' 1,2-diisobutyryl-ethylene or a 1,2-diacetyl-acetylene.

If, in place of a simple butadiene, a A -lvinyl-polyhydronaphthalene or a A J-ethinylpolyhydronaphthalene or a derivative of either is used as parent material, a cyclopentano-polypolyhydronaphthalenes substituted in the 1,2 --diacyl-polyhydrophenanthrenes substituted in 7,-position may be obtained and furthermore dehydrated ,to the phenanthrenes substituted ins-position;

a Example 2 g :3 parts of 1 -vinyl-6-methoxy-3,4-dihydronaphthalene and 1 part of diacetyl ethylenein 25 parts absolute benzene are heatedLfor v48 hours at -115 evaporated C. in a bomb tube. The solution is and ethyl'acetate is added to the resi-' due, whereupon the condensation product cryscyclization product is The -1,15,6-trlmethy1 4,9,7,8-

is a'.c'ol-,

C. (10 mm.).' Its analogous 6-position, I

cyclopentano-polyhydrotallizes out. It may be purified by recrystallization from an ethyl acetate-petroleum ether mixture and then melts at 174-175 C.

In addition to this product, a second, isomeric (JO-CH8 \l (m) (JO-CH:

CnE'uOl 0.7 part of the condensation product melting at 174-175 C. and described in Example 2, 75 is taken up (1,2 diacetyl-7-methoxy 1,2,3,4,9,10 hexahydrophenanthrene: Cal-1220a), is dissolved in 5 parts of benzene, 25 parts of a 0.1 N sodium methylate solution in methanol are added and condensation'productis formed in smaller quan- 5 the whole is boiled for 24 hours on the water tities by the addition of diacetyl-ethylene to 1- bath under reflux. After cooling,it is neutralvinyl-6-methoxy-3,4- dihydronaphthalene, which ized with acetic acid, and, after dilution with remains in the mother-liquors of the product water, the reaction product is extracted with melting, when purified, at 174-175 C. It may ether. The ethereal solution is 'washed, dried be isolated in the following manner: The mother- 10 and evaporated. The residue is dissolved in a liquors are evaporated and the residue is dismixture of equal parts of benzene and petroleum solved in petroleum ether-benzene (1:1). This ether and is purified by filtering through a colsolution is now filtered through a column of acumn of activated aluminium oxide. The column tivated aluminium, the column being washed with is washed with the same solvent and the coma a further quantity of the same solvent mixture. hined filtrates are evaporated. The cyclization The combined, filtrates are evaporated, and the product obtained in this manner is further puriunconverted diacetyl-ethylene removed from the fied by recrystallization from chloroform-peresidue by heating in a high vacuum to 80 C. It troleum ether and then melts at 116-117" C. is hereupon again subjected to chromatographic Analysis of the cyclization product gives the purification by means of aluminium oxide, when, empirical molecular formula CmHuOz. Thus, by extraction with a mixture of equal parts of in addition to the elimination of water, dehydro petroleum ether and benzene, a crystalline fracgenation with loss of two hydrogen atoms has tion, melting point about 105 C., is obtained. I taken place. The dehydrogenation has been The isomeric condensation product is finally obcaused by the atmospheric oxygen, which was tained in a pure state by sublimation in a high not excluded in the cyclization experiment devacuum at 110120 C. It melts at 107l08 C. scribed in this example.

By hydrogenation, using a palladium-calcium The cyclizatlon product C19H1802 is reprecarbonate catalyst, both condensation products sented by one of the two following formulae: yield the same dihydro product. Hydrogenation is preferably carried out in ethyl acetate and proceeds very rapidly. The dihydro product may be recrystallized from ethyl acetate-petroleum ether and melts at l27-.-128 C.

The constitution of the products obtained is illustrated in the formulae below. The condensation product melting at 174-l75 C. is probably represented by Formula I (1,2-diacetyl-1-methor oxy 1,2,3,4,9,10 hexahydrophenanthrene) and the product melting at 107-108 C. by Formula II (1,2-diacetyl-7-methoxy-l,2,3,9,10,11-hexahydrophenanthrene). Formula III represents the dihydro product, which would thus be designated 1,2-diacetyl-I-methoxy- 1,2,3,4,9,10,11,12-octahydrophenanthrene. e (II) (TOO-CH: NCO-CH: C0-C1! (JO-CH CnHuOs 011E110:

Example 4 0.? part of the hydrogenated condensation product 019K240: of melting point l27-128 0., described in Example 2, is heated in 40 parts of a 0.2 N solution of sodium ethylate in absolute alcohol for hours on the water-bath. After cooling the solution is neutralized with acetic acid, diluted with water and the alcohol is evaporated in a vacuum. The reaction product in ether, the ethereal solution I group.

.group, and then treating the washed, dried and evaporated. The residue is dissolved in a mixture of equal parts of ben- After washing with a further quantity of the same solvent mixture, the united filtrates are evaporated-l A cyclizationproduct, C19H22O2, melting at 181-l83 0., is obtained by recrystallizing the thus purified reaction product from an ethyl acetate-petroleum ether mixture. The oxime, prepared in the usual manner, melts at 185-186 C.

The cyclization product is represented by one of the following two formulae:

1. Process for the manufacture of cyclic condensation products, comprising condensing compounds 'which contain a system of conjugated multiple carbon linkages with a member of the group consisting of 1:2-diacyl-ethylenes and 1:2- diacyl-acetylene.

2. Process for the manufacture of cyclic condensation products, comprising condensing compounds which contain a system of conjugated multiple carbon linkages with a member of the group consisting of 1:2-diacyl-ethylenes and 1:2-

group consisting of 3. Process for the manufacture of cyclic condensation products, comprising condensing comwhich contain a system of conjugated multiple carbon linkages with a member of the group consisting of 1 :2-diacyl-ethylenes and 1 :2- diacyl-acetylene, containing in at least one of the two acyl radicals in a-DOSitlOD. a member of the group consisting "of a methylene and a methyl products obtained with dehydrating agents.

4. Process for the manufacture of cyclic condensation products, comprising condensing compounds which contain-a system of conjugated multiple carbon linkages with a member of the group consisting of 1:2-diacyl-ethylenes and 1:2- diacyl-acetylene, containing in at least one of the two acyl radicals in cz-DOSltlOIl a member of the group consisting of a methylene and a methyl group, and then treating the products obtained with dehydrating agents after reduction of double linkages present.

5. Process for the manufacture of cyclic condensation products, comprising condensing compounds which contain a system of conjugated multiple carbon linkages with a member of the group consisting of 1 :Z-diacyl-ethylenes and 1:2- diacyl-acetylene, containing in at least one of the two acyl radicals in a-position a member of the group consisting of a methylene and a methyl group, and then treating the products obtained with dehydrating agents after reduction in part of double linkages presen 6. Process for the manufacture of cyclic condensation products, comprising condensing A 1-vinyl-polyhydro-naphthalenes substituted in 6-position with 1,2-diacetyl-ethylenes, and then treating the products obtained with dehydrating agents, after reduction in part of double linkages present.

7. The cyclic condensation products obtained by condensation of compounds which contain a system of conjugated multiple carbon linkages with compounds being a member of the group consisting of 1:2-diacy -ethylenes and 1:2-diacyl-acetylene.

8. The cyclic condensation products obtained by condensation of compounds which contain a system of conjugated multiple carbon linkages with compounds being a member of the group consisting of 1:2-diacy1-ethylenes and 1:2-diacyl-acetylene containing in at least one of the two acyl radicals in a-POSitiOD. a member of the group consisting of a methylene and a methyl group, followed by dehydration. v

9. The cyclic condensation products obtained by condensation of compounds which contain a system of conjugated multiple carbon linkages with compounds being a member of the group consisting of 1:2-diacyl-ethylenes and 1:2-diacyl-acetylene containing in at least one of the two acyl radicals in u-position a'member of the group consisting of a methylene and a methyl group, followed by dehydration, after reduction of double linkages present.

10. The 1:2-diacyl-7-alkoxy-polyhydro-phenanthrenes.

11. The products obtained by dehydration of a 1:2 diacyl 7 alkoxy-polyhydro-phenanthrene, in at least one MOSES WOLI' GOLDBERG. 

